What is Injectafer?

Injectafer is a prescription iron replacement medicine used for the treatment of iron deficiency anemia (IDA) in adults and children 1 year of age and older who cannot tolerate iron taken by mouth (oral) or who have not responded well to oral iron or adults who have chronic kidney disease who are not on dialysis (non-dialysis dependent chronic kidney disease)

Injectafer is also used for the treatment of iron deficiency in adults with mild to moderate heart failure to improve the ability to exercise (improve exercise capacity).

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What is iron deficiency and how can it relate to certain patients with heart failure?

What Is iron deficiency?

Iron deficiency occurs when the body is deficient (or low) in iron, an essential nutrient.

The connection between iron deficiency and heart failure

If you have heart failure, you may be at a high risk for iron deficiency because of:

Blood droplet and vial icon
Malnutrition
Low iron icon
Iron absorption issues
Fire icon
Chronic inflammation
Heart rhythm icon
Having a more advanced stage of heart failure

Iron deficiency can damage the muscles of the heart and may negatively impact how the heart functions. If you have heart failure, these consequences may aggravate your condition.

Get your levels checked

At your next appointment, ask your healthcare professional when the last time your iron levels were checked and ask if it is time to check them again.

Don't overlook the overlap

Because some of the symptoms of iron deficiency can overlap with and look similar to the symptoms of heart failure, it can be difficult differentiating between the two. Speak with your doctor about any symptoms you may be experiencing.

Iron Deficiency Symptoms

  • Cold hands and feet
  • Irritability
  • Brittle nails
  • Strange food or non-food cravings

Iron Deficiency Symptoms and Heart failure symptoms

  • Fatigue and weakness
  • Irregular heartbeat
  • Difficulty concentrating
  • Shortness of breath
  • Chest pain
  • Lack of appetite

Heart failure symptoms

  • Swelling in the legs, ankles, abdomen, and feet
  • Weight gain
  • Nausea

*Injectafer is not indicated to treat or prevent the symptoms of iron deficiency, heart failure, or the symptoms of iron deficiency in heart failure.

How iron deficiency in mild to moderate heart failure patients can impact exercise capacity  

As heart failure progresses, symptoms may worsen, reducing physical activity and exercise capacity. This is especially true if you have iron deficiency that remains undiagnosed and/or untreated. Prepare for your next appointment by continuing to evaluate your day-to-day routine and how much exercise you're able to do.

How is iron deficiency diagnosed?

50% of people with heart failure have iron deficiency
50% of people with heart failure have iron deficiency

Iron deficiency may occur in adult patients with heart failure. Lab tests that look at iron levels are used to help determine if you have iron deficiency. These tests include checking your ferritin, transferrin saturation (TSAT), and Hb levels. Open communication with your healthcare professional is important to help you understand what labs are being ordered and why.

How can you tell from your lab values if you may have iron deficiency in heart failure?†‡ Check to see if your:

  • Ferritin levels are below 100 ng/mL
  • Ferritin levels are between 100 ng/mL and 300 ng/mL, if your TSAT is <20%

Are you a part of the ~50% of people who have iron deficiency and heart failure?

†Normal values can vary for many reasons, including conditions you may have or where your lab work was done. That's why it's important to discuss your lab results with your healthcare professional to find out what those results mean.

‡Your healthcare professional may also look at your hemoglobin (Hb) levels.

The possible benefits of Injectafer

The information on this website should not take the place of talking with your healthcare professional. If you have any questions about your condition, or if you want more information about iron deficiency anemia, iron deficiency in heart failure, or Injectafer, talk to your healthcare professional. Only your healthcare professional can decide if Injectafer is right for you.

IMPORTANT SAFETY INFORMATION Expand

Who should not receive Injectafer?

You should not receive Injectafer if you are allergic to ferric carboxymaltose or any of the other ingredients in Injectafer. The active ingredient in Injectafer is ferric carboxymaltose, the inactive ingredients are: water for injection, sodium hydroxide or hydrochloric acid.

What should I tell my healthcare provider before receiving Injectafer?

Before you receive Injectafer, tell your healthcare provider about all of your medical conditions, including if you:

Injectafer® (ferric carboxymaltose injection) is available by prescription only. Ask your healthcare provider if Injectafer is right for you.

What is Injectafer?

Injectafer is a prescription iron replacement medicine used for the treatment of:

  • iron deficiency anemia (IDA) in:
    • adults and children 1 year of age and older who cannot tolerate iron taken by mouth (oral) or who have not responded well to oral iron
    • adults who have chronic kidney disease who are not on dialysis (non-dialysis dependent chronic kidney disease)
  • iron deficiency in adults with mild to moderate heart failure to improve the ability to exercise (improve exercise capacity)

It is not known if Injectafer is safe and effective in children with IDA who are under 1 year of age.

It is not known if Injectafer is safe and effective in children with iron deficiency and mild to moderate heart failure to improve exercise capacity.

IMPORTANT SAFETY INFORMATION

Who should not receive Injectafer?

You should not receive Injectafer if you are allergic to ferric carboxymaltose or any of the other ingredients in Injectafer. The active ingredient in Injectafer is ferric carboxymaltose, the inactive ingredients are: water for injection, sodium hydroxide or hydrochloric acid.

What should I tell my healthcare provider before receiving Injectafer?

Before you receive Injectafer, tell your healthcare provider about all of your medical conditions, including if you:

  • have had an allergic reaction to iron given into your vein
  • have a history of trouble absorbing certain vitamins or phosphate in your body
  • have inflammatory bowel disease
  • have hyperparathyroidism
  • have low vitamin D levels
  • have high blood pressure
  • have previously received Injectafer
  • are pregnant or plan to become pregnant. Injectafer may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with Injectafer
  • are breastfeeding or plan to breastfeed. Injectafer passes into your breast milk. It is not known if Injectafer will harm your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with Injectafer

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive Injectafer?

Injectafer is given into your vein (intravenously) by your healthcare provider.

Injectafer is usually given in 2 doses at least 7 days apart for iron deficiency anemia or 6 weeks apart for iron deficiency with mild to moderate heart failure to improve exercise capacity.

If your healthcare provider decides it is right for you, Injectafer may be given intravenously by your healthcare provider as a single-dose treatment.

Injectafer treatment may be repeated if your healthcare provider decides it is needed.

What are the possible side effects of Injectafer?

Injectafer may cause serious side effects, including:

  • Allergic reactions. Serious life-threatening allergic reactions that can lead to death have happened in people who receive Injectafer and may include the following signs or symptoms:
    • low blood pressure
    • feeling dizzy or lightheaded
    • loss of consciousness
    • trouble breathing
    • swelling
    • fast heartbeat
    • cold or clammy skin
    • feet or hands turn blue
    • itching
    • rash
    • hives
    • wheezing

    Your healthcare provider will watch you during and for at least 30 minutes after you receive Injectafer. Tell your healthcare provider right away if you develop any signs or symptoms of allergic reactions during or after treatment with Injectafer

  • Symptoms of low blood phosphate levels. Injectafer may cause low levels of phosphate in your blood that may be serious and can lead to softening of your bones and broken bones (fractures), especially in people who have received multiple Injectafer treatments. Your healthcare provider may check your blood phosphate levels before a repeat treatment with Injectafer if you are at risk for low blood phosphate levels. If a repeat treatment is needed within 3 months of your last treatment, your healthcare provider should check your blood phosphate levels. Tell your healthcare provider if you develop any of the following signs or symptoms of low blood phosphate levels during treatment with Injectafer:
    • feeling very tired
    • muscle weakness or pain
    • bone or joint pain
    • broken bones
  • High blood pressure. High blood pressure, sometimes with redness and warmth of the face (facial flushing), dizziness, or nausea, has happened during treatment with Injectafer. Your healthcare provider will check your blood pressure and check for any signs and symptoms of high blood pressure after you receive Injectafer

The most common side effects of Injectafer include:

  • In adults:
    • nausea
    • high blood pressure
    • flushing
    • injection site reactions
    • skin redness
    • low levels of phosphate in your blood
    • dizziness
  • In children:
    • low levels of phosphate in your blood
    • injection site reactions
    • rash
    • headache
    • vomiting

These are not all of the possible side effects of Injectafer.

Call your healthcare provider for medical advice about side effects.

To report side effects, contact American Regent at 1-800-734-9236 or Email: pv@americanregent.com Fax: 1-610-650-0170.

You may also report side effects to the FDA at 1-800-332-1088 or www.fda.gov/medwatch.

The risk information provided here is not comprehensive. To learn more about Injectafer, talk with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.americanregent.com.

Please see Full Prescribing Information for Injectafer.

IMPORTANT SAFETY INFORMATION Expand

Who should not receive Injectafer?

You should not receive Injectafer if you are allergic to ferric carboxymaltose or any of the other ingredients in Injectafer. The active ingredient in Injectafer is ferric carboxymaltose, the inactive ingredients are: water for injection, sodium hydroxide or hydrochloric acid.

Injectafer® (ferric carboxymaltose injection) is available by prescription only. Ask your healthcare provider if Injectafer is right for you.

What is Injectafer?

Injectafer is a prescription iron replacement medicine used for the treatment of:

  • iron deficiency anemia (IDA) in:
    • adults and children 1 year of age and older who cannot tolerate iron taken by mouth (oral) or who have not responded well to oral iron
    • adults who have chronic kidney disease who are not on dialysis (non-dialysis dependent chronic kidney disease)
  • iron deficiency in adults with mild to moderate heart failure to improve the ability to exercise (improve exercise capacity)

It is not known if Injectafer is safe and effective in children with IDA who are under 1 year of age.

It is not known if Injectafer is safe and effective in children with iron deficiency and mild to moderate heart failure to improve exercise capacity.

IMPORTANT SAFETY INFORMATION

Who should not receive Injectafer?

You should not receive Injectafer if you are allergic to ferric carboxymaltose or any of the other ingredients in Injectafer. The active ingredient in Injectafer is ferric carboxymaltose, the inactive ingredients are: water for injection, sodium hydroxide or hydrochloric acid.

What should I tell my healthcare provider before receiving Injectafer?

Before you receive Injectafer, tell your healthcare provider about all of your medical conditions, including if you:

  • have had an allergic reaction to iron given into your vein
  • have a history of trouble absorbing certain vitamins or phosphate in your body
  • have inflammatory bowel disease
  • have hyperparathyroidism
  • have low vitamin D levels
  • have high blood pressure
  • have previously received Injectafer
  • are pregnant or plan to become pregnant. Injectafer may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with Injectafer
  • are breastfeeding or plan to breastfeed. Injectafer passes into your breast milk. It is not known if Injectafer will harm your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with Injectafer

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive Injectafer?

Injectafer is given into your vein (intravenously) by your healthcare provider.

Injectafer is usually given in 2 doses at least 7 days apart for iron deficiency anemia or 6 weeks apart for iron deficiency with mild to moderate heart failure to improve exercise capacity.

If your healthcare provider decides it is right for you, Injectafer may be given intravenously by your healthcare provider as a single-dose treatment.

Injectafer treatment may be repeated if your healthcare provider decides it is needed.

What are the possible side effects of Injectafer?

Injectafer may cause serious side effects, including:

  • Allergic reactions. Serious life-threatening allergic reactions that can lead to death have happened in people who receive Injectafer and may include the following signs or symptoms:
    • low blood pressure
    • feeling dizzy or lightheaded
    • loss of consciousness
    • trouble breathing
    • swelling
    • fast heartbeat
    • cold or clammy skin
    • feet or hands turn blue
    • itching
    • rash
    • hives
    • wheezing

    Your healthcare provider will watch you during and for at least 30 minutes after you receive Injectafer. Tell your healthcare provider right away if you develop any signs or symptoms of allergic reactions during or after treatment with Injectafer

  • Symptoms of low blood phosphate levels. Injectafer may cause low levels of phosphate in your blood that may be serious and can lead to softening of your bones and broken bones (fractures), especially in people who have received multiple Injectafer treatments. Your healthcare provider may check your blood phosphate levels before a repeat treatment with Injectafer if you are at risk for low blood phosphate levels. If a repeat treatment is needed within 3 months of your last treatment, your healthcare provider should check your blood phosphate levels. Tell your healthcare provider if you develop any of the following signs or symptoms of low blood phosphate levels during treatment with Injectafer:
    • feeling very tired
    • muscle weakness or pain
    • bone or joint pain
    • broken bones
  • High blood pressure. High blood pressure, sometimes with redness and warmth of the face (facial flushing), dizziness, or nausea, has happened during treatment with Injectafer. Your healthcare provider will check your blood pressure and check for any signs and symptoms of high blood pressure after you receive Injectafer

The most common side effects of Injectafer include:

  • In adults:
    • nausea
    • high blood pressure
    • flushing
    • injection site reactions
    • skin redness
    • low levels of phosphate in your blood
    • dizziness
  • In children:
    • low levels of phosphate in your blood
    • injection site reactions
    • rash
    • headache
    • vomiting

These are not all of the possible side effects of Injectafer.

Call your healthcare provider for medical advice about side effects.

To report side effects, contact American Regent at 1-800-734-9236 or Email: pv@americanregent.com Fax: 1-610-650-0170.

You may also report side effects to the FDA at 1-800-332-1088 or www.fda.gov/medwatch.

The risk information provided here is not comprehensive. To learn more about Injectafer, talk with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.americanregent.com or call 1-800-645-1706.

Please see Full Prescribing Information for Injectafer.

To contact us with questions or concerns about an American Regent product, please call us: 888-354-4855.

Injectafer® and the Injectafer® logo are trademarks of Vifor (International) Inc., Switzerland. Injectafer® is manufactured under license from Vifor (International) Inc., Switzerland. Trademarks not owned by American Regent, Inc. or Vifor (International) are the property of their respective owners.

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